The International IgA Nephropathy Network Prediction Tool Underestimates Disease Progression in Indian Patients.

ABSTRACT:

Introduction

International IgA nephropathy (IgAN) network (IIgANN) prediction tool was developed to predict risk of progression in IgAN. We attempted to externally validate this tool in an Indian cohort because the original study did not include Indian patients.

Methods

Adult patients with primary IgAN were stratified to low, intermediate, higher, and highest risk groups, as per the original model. Primary outcome was reduction in estimated glomerular filtration rate (eGFR) by >50% or kidney failure. Both models were evaluated using discrimination: concordance statistics (C-statistics), time-dependent receiver operating characteristic (ROC) curves, R²d, Kaplan-Meier survival curves between risk groups and calibration plots. Reclassification with net reclassificati

SUBMITTER: Bagchi S 

PROVIDER: S-EPMC9171624 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature