Ontology highlight
ABSTRACT:
SUBMITTER: Zheng Y
PROVIDER: S-EPMC9171633 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Zheng Yuyuan Y Ding Lei L Meng Xianhui X Potter Meg M Kearney Alison L AL Zhang Jie J Sun Jie J James David E DE Yang Guang G Zhou Chun C
Proceedings of the National Academy of Sciences of the United States of America 20220506 19
Over the years it has been established that SIN1, a key component of mTORC2, could interact with Ras family small GTPases through its Ras-binding domain (RBD). The physical association of Ras and SIN1/mTORC2 could potentially affect both mTORC2 and Ras-ERK pathways. To decipher the precise molecular mechanism of this interaction, we determined the high-resolution structures of HRas/KRas-SIN1 RBD complexes, showing the detailed interaction interface. Mutation of critical interface residues abolis ...[more]