Autophagy induced by taurolidine protects against polymicrobial sepsis by promoting both host resistance and disease tolerance.

ABSTRACT: Sepsis, septic shock, and their sequelae are the leading causes of death in intensive care units, with limited therapeutic options. Disease resistance and tolerance are two evolutionarily conserved yet distinct defense strategies that protect the host against microbial infection. Here, we report that taurolidine administered at 6 h before septic challenge led to strong protection against polymicrobial sepsis by promoting both host resistance and disease tolerance characterized by accelerated bacterial clearance, ameliorated organ damage, and diminished vascular and gut permeability. Notably, taurolidine administered at 6 h after septic challenge also rescued mice from sepsis-associated lethality by enhancing disease tolerance to tissue and organ injury. Importantly, this in vivo protection

SUBMITTER: Huang J 

PROVIDER: S-EPMC9171638 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature