Dual control of dopamine in Drosophila myeloid-like progenitor cell proliferation and regulation of lymph gland growth.

ABSTRACT: In Drosophila, definitive haematopoiesis takes place in a specialized organ termed "lymph gland". It harbours multi-potent stem-like blood progenitor cells whose development controls overall growth of this haematopoietic tissue and formation of mature blood cells. With respect to its development, neurotransmitters have emerged as potent regulators of blood-progenitor cell development and function. In this study, we extend our understanding of neurotransmitters and show that progenitors are self-sufficient with regard to synthesizing dopamine, a well-established neurotransmitter. These cells also have modules for dopamine sensing through the receptor and transporter. We found that modulating expression of these components in progenitor cells affected lymph gland growth, which suggested grow

SUBMITTER: Kapoor A 

PROVIDER: S-EPMC9171693 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature