Treatment Effect of Long-Term Antipsychotics on Default-Mode Network Dysfunction in Drug-Naive Patients With First-Episode Schizophrenia: A Longitudinal Study.

ABSTRACT: Background: The maintenance of antipsychotic treatment is an efficient way to prevent the relapse of schizophrenia (SCZ). Previous studies have identified beneficial effects of antipsychotics on brain structural and functional abnormalities during mostly the acute phase in SCZ, but seldom is known about the effects of long-term antipsychotics on the brain. The present study focused on the long-term antipsychotic effect on the default mode network (DMN) dysfunction in SCZ. Methods: A longitudinal study of the functional connectivity (FC) of 11 DMN subdivisions was conducted in 86 drug-naive first-episode patients with SCZ at the baseline and after a long-term atypical antipsychotic treatment (more than 6 months) based on the resting-state functional magnetic resonance image. I

SUBMITTER: Deng M 

PROVIDER: S-EPMC9171718 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature