Partition of respiratory mechanics in patients with acute respiratory distress syndrome and association with outcome: a multicentre clinical study.

ABSTRACT:

Purpose

In acute respiratory distress syndrome (ARDS), physiological parameters associated with outcome may help defining targets for mechanical ventilation. This study aimed to address whether transpulmonary pressures (P_L), including transpulmonary driving pressure (DP_L), elastance-derived plateau P_L, and directly-measured end-expiratory P_L, are better associated with 60-day outcome than airway driving pressure (DP_aw). We also tested the combination of oxygenation and stretch index [PaO₂/(FiO₂*DP_aw)].

Methods

Prospective, observational, multicentre registry of ARDS patients. Respiratory mechanics were measured early after intubation at 6 kg/ml tidal volume. We compared the predictive pow

SUBMITTER: Chen L 

PROVIDER: S-EPMC9171739 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature