TRPC4 and GIRK channels underlie neuronal coding of firing patterns that reflect G_q/11-G_i/o coincidence signals of variable strengths.

ABSTRACT: Transient receptor potential canonical 4 (TRPC4) is a receptor-operated cation channel codependent on both the Gq/11–phospholipase C signaling pathway and Gi/o proteins for activation. This makes TRPC4 an excellent coincidence sensor of neurotransmission through Gq/11- and Gi/o-coupled receptors. In whole-cell slice recordings of lateral septal neurons, TRPC4 mediates a strong depolarizing plateau that shuts down action potential firing, which may or may not be followed by a hyperpolarization that extends the firing pause to varying durations depending on the strength of Gi/o stimulation. We show that the depolarizing plateau is codependent on Gq/11-coupled group I metabotropic glutamate receptors and on Gi/o-coupled γ-aminobutyric acid type B receptors. The hyperpolarization is mediated b

SUBMITTER: Tian JB 

PROVIDER: S-EPMC9171772 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature