A unidirectional but not uniform striatal landscape of dopamine signaling for motivational stimuli.

ABSTRACT: Dopamine signals in the striatum are critical for motivated behavior. However, their regional specificity and precise information content are actively debated. Dopaminergic projections to the striatum are topographically organized. Thus, we quantified dopamine release in response to motivational stimuli and associated predictive cues in six principal striatal regions of unrestrained, behaving rats. Absolute signal size and its modulation by stimulus value and by subjective state of the animal were interregionally heterogeneous on a medial to lateral gradient. In contrast, dopamine-concentration direction of change was homogeneous across all regions: appetitive stimuli increased and aversive stimuli decreased dopamine concentration. Although cues predictive of such motivational stimuli acqu

SUBMITTER: van Elzelingen W 

PROVIDER: S-EPMC9171911 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature