Hippocampal-medial prefrontal cortex network dynamics predict performance during retrieval in a context-guided object memory task.

ABSTRACT: Remembering life episodes is a complex process that requires interaction among multiple brain areas. It is thought that contextual information provided by the hippocampus (HPC) can trigger the recall of a past event through the activation of medial prefrontal cortex (mPFC) neuronal ensembles, but the underlying mechanisms remain poorly understood. However, little is known about the coordinated activity between these structures during recall. We performed electrophysiological recordings in behaving rats during the retrieval phase of the object-in-context (OIC) memory task. Context-guided recognition of objects in this task requires the activity of both the mPFC and the ventral HPC (vHPC). Coherence, phase locking, and theta amplitude correlation analysis showed an increase in vHPC-mPFC LFP

SUBMITTER: Morici JF 

PROVIDER: S-EPMC9171913 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature