Phylogeny-guided microbiome OTU-specific association test (POST).

ABSTRACT:

Background

The relationship between host conditions and microbiome profiles, typically characterized by operational taxonomic units (OTUs), contains important information about the microbial role in human health. Traditional association testing frameworks are challenged by the high dimensionality and sparsity of typical microbiome profiles. Phylogenetic information is often incorporated to address these challenges with the assumption that evolutionarily similar taxa tend to behave similarly. However, this assumption may not always be valid due to the complex effects of microbes, and phylogenetic information should be incorporated in a data-supervised fashion.

Results

In this work, we propose a local collapsing test called phylogeny-guided microbiome OTU-specific association

SUBMITTER: Huang C 

PROVIDER: S-EPMC9171974 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature