The genomic and transcriptome characteristics of lung adenocarcinoma patients with previous breast cancer.

ABSTRACT:

Background

Breast cancer and lung cancer are the top two malignancies in the female population and the number of patients with breast cancer and subsequent primary lung cancer has increased significantly in recent years. However, the unique molecular characteristics of this group of patients remains unclear.

Purpose

To identify the genomic and transcriptome characteristics of primary lung adenocarcinoma patients with previous breast cancer by comparison with single primary lung adenocarcinoma (SPLA) patients.

Methods

The tumor and normal pulmonary tissue specimens of ten primary pulmonary adenocarcinoma patients with previous breast cancer (multiple primary cancer, MPC) and ten SPLA patients were prospectively collected. The whole exome sequencing (WES) and RNA sequen

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9171992 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature