Optogenetic inactivation of the medial septum impairs long-term object recognition memory formation.

ABSTRACT: Theta is one of the most prominent extracellular synchronous oscillations in the mammalian brain. Hippocampal theta relies on an intact medial septum (MS) and has been consistently recorded during the training phase of some learning paradigms, suggesting that it may be implicated in hippocampus-dependent long-term memory processing. Object recognition memory (ORM) allows animals to identify familiar items and is essential for remembering facts and events. In rodents, long-term ORM formation requires a functional hippocampus but the involvement of the MS in this process remains controversial. We found that training adult male Wistar rats in a long-term ORM-inducing learning task involving exposure to two different, but behaviorally equivalent novel stimuli objects increased hippocampal thet

SUBMITTER: Gonzalez MC 

PROVIDER: S-EPMC9172102 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature