Functional amyloids from bacterial biofilms - structural properties and interaction partners.

ABSTRACT: Protein aggregation and amyloid formation have historically been linked with various diseases such as Alzheimer's and Parkinson's disease, but recently functional amyloids have gained a great deal of interest in not causing a disease and having a distinct function in vivo. Functional bacterial amyloids form the structural scaffold in bacterial biofilms and provide a survival strategy for the bacteria along with antibiotic resistance. The formation of functional amyloids happens extracellularly which differs from most disease related amyloids. Studies of functional amyloids have revealed several distinctions compared to disease related amyloids including primary structures designed to optimize amyloid formation while still retaining a controlled assembly of the individual subunits in

SUBMITTER: Akbey U 

PROVIDER: S-EPMC9172111 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature