In-silico and in-vitro studies on the efficacy of mangiferin against colorectal cancer.

ABSTRACT:

Background

Mangiferin is a C-glycoside xanthone molecule having a wide range of therapeutic properties. Hence, the present study aims to understand the efficacy of mangiferin against colorectal cancer (CRC) and to elucidate the mechanisms of action of mangiferin on colorectal cancer.

Method

The molecular mechanism of mangiferin against colorectal cancer was studied using Autodock Vina software. Pharmacophore analysis of mangiferin concerning five COX-2 inhibitor drugs was carried out using the PharmaGist server to analyze the possibility of using mangiferin as a COX-2 inhibitor. In vitro analysis of Mangiferin against various cancer cell lines was performed.

Results

The molecular mechanism of action of mangiferin against CRC was assessed by docking with multiple targe

SUBMITTER: Samadarsi R 

PROVIDER: S-EPMC9172119 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature