The role of Toll-like receptors and neuroinflammation in Parkinson's disease.

ABSTRACT:

Background

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, characterized by motor and non-motor symptoms, significantly affecting patients' life. Pathologically, PD is associated with the extensive degeneration of dopaminergic neurons in various regions of the central nervous system (CNS), specifically the substantia nigra. This neuronal loss is accompanied by the aggregation of misfolded protein, named α-synuclein.

Main text

Recent studies detected several clues of neuroinflammation in PD samples using postmortem human PD brains and various PD animal models. Some evidence of neuroinflammation in PD patients included higher levels of proinflammatory cytokines in serum and cerebrospinal fluid (CSF), presence of activated microglia in various

SUBMITTER: Heidari A 

PROVIDER: S-EPMC9172200 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature