Cell surface photoengineering enables modeling of glycocalyx shedding dynamics.

ABSTRACT: The cellular glycocalyx, composed of membrane associated glycoproteins and glycolipids, is a complex and dynamic interface that facilitates interactions between cells and their environment. The glycocalyx composition is continuously changing through biosynthesis of new glycoconjugates and membrane turnover. Various glycocalyx components, such as mucins, can also be rapidly shed from the cell surface in response to acute events, such as pathogenic threat. Mucins, which are large extended glycoproteins, deliver important protective functions against infection by creating a physical barrier at the cell surface and by capturing and clearing pathogens through shedding. Evaluating these mucin functions may provide better understanding of early stages of pathogenesis; however, tools to tailor the

SUBMITTER: Purcell SC 

PROVIDER: S-EPMC9172368 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature