The Pathophysiological Roles of Regulatory T Cells in the Early Phase of Systemic Sclerosis.

ABSTRACT: Systemic sclerosis (SSc) is an autoimmune disease that is characterized by vascular damage and fibrosis. Both clinical manifestations and immunological disturbances are diverse according to the disease duration. Particularly, changes in immunological processes are prominent in the early phase of SSc. The orchestration of several subsets of immune cells promotes autoimmune responses and inflammation, and eventually stimulates pro-fibrotic processes. Many reports have indicated that CD4⁺ T cells play pivotal roles in pathogenesis in the early phase of SSc. In particular, the pathogenic roles of regulatory T (Treg) cells have been investigated. Although the results were controversial, recent reports suggested an increase of Treg cells in the early phase of SSc patients. Treg cells

SUBMITTER: Kobayashi S 

PROVIDER: S-EPMC9172592 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature