Distinct Gene Expression Patterns of Calcium Channels and Related Signaling Pathways Discovered in Lymphomas.

ABSTRACT: Cell surface calcium (Ca²⁺) channels permit Ca²⁺ ion influx, with Ca²⁺ taking part in cellular functions such as proliferation, survival, and activation. The expression of voltage-dependent Ca²⁺ (Ca_V) channels may modulate the growth of hematologic cancers. Profile analysis of Ca²⁺ channels, with a focus on the Ca²⁺ release-activated Ca²⁺ (CRAC) and L-type Ca_V channels, was performed on RNA sequencing data from lymphoma cell lines and samples derived from patients with diffuse large B cell lymphoma (DLBCL). Ca_V1.2 expression was found to be elevated in classical Hodgkin lymphoma (CHL) cell lines when compared to other B cell lymphoma cell lines. In contrast, CHL exhibited reduced e

SUBMITTER: Stanwood SR 

PROVIDER: S-EPMC9172636 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature