The Case for Case-Cohort: An Applied Epidemiologist's Guide to Reframing Case-Cohort Studies to Improve Usability and Flexibility.

ABSTRACT: When research questions require the use of precious samples, expensive assays or equipment, or labor-intensive data collection or analysis, nested case-control or case-cohort sampling of observational cohort study participants can often reduce costs. These study designs have similar statistical precision for addressing a singular research question, but case-cohort studies have broader efficiency and superior flexibility. Despite this, case-cohort designs are comparatively underutilized in the epidemiologic literature. Recent advances in statistical methods and software have made analyses of case-cohort data easier to implement, and advances from casual inference, such as inverse probability of sampling weights, have allowed the case-cohort design to be used with a variety of target paramet

SUBMITTER: O'Brien KM 

PROVIDER: S-EPMC9172927 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature