An approach to cellular tropism of SARS-CoV-2 through protein-protein interaction and enrichment analysis.

ABSTRACT: COVID-19, caused by SARS-CoV-2, is a primarily pulmonary disease that can affect several organs, directly or indirectly. To date, there are many questions about the different pathological mechanisms. Here, we generate an approach to identify the cellular-level tropism of SARS-CoV-2 using human proteomics, virus-host interactions, and enrichment analysis. Through a network-based approach, the molecular context was visualized and analyzed. This procedure was also performed for SARS-CoV-1. We obtained proteomes and interactomes from 145 different cells corresponding to 57 different tissues. We discarded the cells without the proteins known for interacting with the virus, such as ACE2 or TMPRSS2. Of the remaining cells, a gradient of susceptibility to infection was observed. In addition, we id

SUBMITTER: Ortega-Bernal D 

PROVIDER: S-EPMC9172986 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature