Endocannabinoid System in Polycystic Kidney Disease.

ABSTRACT:

Introduction

Autosomal dominant polycystic kidney disease (ADPKD) is a commonly inherited disorder characterized by renal cyst formation. A major pathological feature of ADPKD is the development of interstitial inflammation. The endocannabinoid (EC) system is present in the kidney and has recently emerged as an important player in inflammation and the pathogenesis of progressive kidney disease.

Methods

Data on ECs were collected using a validated mass spectrometry assay from a well-characterized cohort of 102 ADPKD patients (at baseline and after 2- and 4 years on standard vs. rigorous blood-pressure control) and compared to 100 healthy subjects.

Results

Compared to healthy individuals, we found higher interleukins-6 and -1b as well as reduced plasma levels of anandam

SUBMITTER: Klawitter J 

PROVIDER: S-EPMC9173653 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature