Identification of a Necroptosis-Related Prognostic Index and Associated Regulatory Axis in Kidney Renal Clear Cell Carcinoma.

ABSTRACT:

Background

Kidney renal clear cell carcinoma (KIRC) is one of the most common aggressive malignancies in the genitourinary system with the high degree of immune infiltration. However, the role of necroptosis-related genes in the immune infiltration of KIRC and the impact on overall survival have not been adequately studied.

Methods

Differentially expressed necroptosis-related genes were identified based on The Cancer Genome Atlas (TCGA). Then, we constructed a necroptosis-related prognostic index (NRPI) through Lasso Cox regression analysis. The KIRC patients were divided into NRPI-high and NRPI-low groups by the median. Univariate and multivariate Cox regression analyses were used to determine NRPI as an independent prognostic factor. The role of NRPI was assessed through n

SUBMITTER: Luo Y 

PROVIDER: S-EPMC9173730 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature