Modified viral-genetic mapping reveals local and global connectivity relationships of ventral tegmental area dopamine cells.

ABSTRACT: Dopamine cells in the ventral tegmental area (VTA^DA) are critical for a variety of motivated behaviors. These cells receive synaptic inputs from over 100 anatomically defined brain regions, which enables control from a distributed set of inputs across the brain. Extensive efforts have been made to map inputs to VTA cells based on neurochemical phenotype and output site. However, all of these studies have the same fundamental limitation that inputs local to the VTA cannot be properly assessed due to non-Cre-dependent uptake of EnvA-pseudotyped virus. Therefore, the quantitative contribution of local inputs to the VTA, including GABAergic, DAergic, and serotonergic, is not known. Here, I used a modified viral-genetic strategy that enables examination of both local and long-range i

SUBMITTER: Beier K 

PROVIDER: S-EPMC9173742 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature