Understanding the mutational frequency in SARS-CoV-2 proteome using structural features.

ABSTRACT: The prolonged transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus in the human population has led to demographic divergence and the emergence of several location-specific clusters of viral strains. Although the effect of mutation(s) on severity and survival of the virus is still unclear, it is evident that certain sites in the viral proteome are more/less prone to mutations. In fact, millions of SARS-CoV-2 sequences collected all over the world have provided us a unique opportunity to understand viral protein mutations and develop novel computational approaches to predict mutational patterns. In this study, we have classified the mutation sites into low and high mutability classes based on viral isolates count containing mutations. The physicochemical fea

SUBMITTER: Rawat P 

PROVIDER: S-EPMC9173821 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature