Site-Specific Detection and Characterization of Ubiquitin Carbamylation.

ABSTRACT: The physiological consequences of varying in vivo CO₂ levels point to a general mechanism for CO₂ to influence cellular homeostasis beyond regulating pH. Aside from a few instances where CO₂ has been observed to cause post-translational protein modification, by forming long-lived carbamates, little is known about how transitory and ubiquitous carbamylation events could induce a physiological response. Ubiquitin is a versatile protein involved in a multitude of cellular signaling pathways as polymeric chains of various lengths formed through one of the seven lysines or N-terminal amine. Unique polyubiquitin (polyUb) compositions present recognition signals for specific ubiquitin-receptors which enables this one protein to be involved in many different cellul

SUBMITTER: Pawloski W 

PROVIDER: S-EPMC9173829 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature