Synergistic anti-proliferative activity of JQ1 and GSK2801 in triple-negative breast cancer.

ABSTRACT:

Background

Triple-negative breast cancer (TNBC) constitutes 10-20% of breast cancers and is challenging to treat due to a lack of effective targeted therapies. Previous studies in TNBC cell lines showed in vitro growth inhibition when JQ1 or GSK2801 were administered alone, and enhanced activity when co-administered. Given their respective mechanisms of actions, we hypothesized the combinatorial effect could be due to the target genes affected. Hence the target genes were characterized for their expression in the TNBC cell lines to prove the combinatorial effect of JQ1 and GSK2801.

Methods

RNASeq data sets of TNBC cell lines (MDA-MB-231, HCC-1806 and SUM-159) were analyzed to identify the differentially expressed genes in single and combined treatments. The topmost downregul

SUBMITTER: Yellapu NK 

PROVIDER: S-EPMC9173973 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature