Imaging Adipose Tissue Browning using Mitochondrial Complex-I Tracer [¹⁸F]BCPP-EF.

ABSTRACT: Browning of white adipose tissue (WAT) into beige adipocytes has been proposed as a strategy to tackle the ongoing obesity epidemic. Thermogenic stimuli have been investigated with the aim of converting existing white adipose tissue, primarily used for energy storage, into beige adipocytes capable of dissipating energy; however, evaluation is complicated by the dearth of noninvasive methodologies to quantify de novo beige adipocytes in WAT. Imaging with [¹⁸F]FDG is commonly used to measure brown adipose tissue (BAT) and beige adipocytes but the relationship between beige adipocytes, thermogenesis and [¹⁸F]FDG uptake is unclear. [¹⁸F]BCPP-EF, a tracer for mitochondrial complex-I (MC-I), acts as a marker of oxidative metabolism and may be useful for th

SUBMITTER: Goggi JL 

PROVIDER: S-EPMC9173993 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature