Anticardiolipin Autoantibodies as Useful Biomarkers for the Prediction of Mortality in Septic Patients.

ABSTRACT:

Background

The detection of antiphospholipid antibodies (aPL) is of interest because of their importance in the pathogenesis of arterial or venous thrombosis. They could be a "second hit" of an inflammatory event such as infection. The aim of our study was to assess the performance of antiphospholipid antibody biomarker to predict in-hospital mortality in intensive care unit (ICU) septic patients.

Methods

We conducted a prospective single-center observational study including consecutive critically ill septic adults admitted to the intensive care unit. Clinical and laboratory data including enzyme-linked immunosorbent assay for antiphospholipid antibodies (anticardiolipin (aCL), antiphosphatidylserine (aPS)) were obtained. Blood samples were collected on days 1, 3, 5, 8, and

SUBMITTER: Abouda A 

PROVIDER: S-EPMC9174012 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature