Phenotypic and genetic associations of quantitative magnetic susceptibility in UK Biobank brain imaging.

ABSTRACT: A key aim in epidemiological neuroscience is identification of markers to assess brain health and monitor therapeutic interventions. Quantitative susceptibility mapping (QSM) is an emerging magnetic resonance imaging technique that measures tissue magnetic susceptibility and has been shown to detect pathological changes in tissue iron, myelin and calcification. We present an open resource of QSM-based imaging measures of multiple brain structures in 35,273 individuals from the UK Biobank prospective epidemiological study. We identify statistically significant associations of 251 phenotypes with magnetic susceptibility that include body iron, disease, diet and alcohol consumption. Genome-wide associations relate magnetic susceptibility to 76 replicating clusters of genetic variants with bio

SUBMITTER: Wang C 

PROVIDER: S-EPMC9174052 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature