Circulating SSEA-1⁺ stem cell-mediated tissue repair in allergic airway inflammation.

ABSTRACT: Structural changes known as airway remodeling characterize chronic/severe asthma and contribute to lung dysfunction. We previously reported that neonatal SSEA-1⁺ pulmonary stem/progenitor cells (PSCs) ameliorated airway inflammation in asthmatic mice. However, the molecular mechanisms by which endogenous SSEA-1⁺ PSC of adult mice afford beneficial effects in alveolar homeostasis and lung repair after allergen challenge remain incompletely understood. To analyze the expression profile and clarify the biological significance of endogenous adult lung SSEA-1⁺ cells in asthmatic mice. Lung SSEA-1⁺ cells and circulating SSEA-1⁺ cells in peripheral blood were determined by confocal microscopy and cytometric analysis. GFP chimeric mice were us

SUBMITTER: Chiu CJ 

PROVIDER: S-EPMC9174110 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature