Development of a Drum Tower Severity Scoring (DTSS) system for pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome.

ABSTRACT:

Background and aims

There has been no reliable severity system based on the prognosis to guide therapeutic strategies for patients with pyrrolizidine alkaloid (PA)-induced hepatic sinusoidal obstruction syndrome (HSOS). We aimed to create a novel Drum Tower Severity Scoring (DTSS) system for these patients to guide therapy.

Methods

172 Patients with PA-HSOS who received supportive care and anticoagulation therapy in Nanjing Drum Tower Hospital from January 2008 to December 2020 were enrolled and analyzed retrospectively. These patients were randomized into a training or validation set in a 3:1 ratio. Next, we established and validated the newly developed DTSS system.

Results

Analysis identified a predictive formula: logit (P) = 0.004 × aspartate aminotransferase (AST,

SUBMITTER: Wang X 

PROVIDER: S-EPMC9174127 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature