Oxidative Stress Predicts Post-Surgery Complications in Gastrointestinal Cancer Patients.

ABSTRACT:

Introduction

An excessive perioperative inflammatory reaction can lead to more postoperative complications in patients treated for gastrointestinal cancers. It has been suggested that this inflammatory reaction leads to oxidative stress. The most important nonenzymatic antioxidants are serum free thiols. The purpose of this study was to evaluate whether high preoperative serum free thiol levels are associated with short-term clinical outcomes.

Methods

Blood samples were drawn before, at the end of, and 1 and 2 days after surgery of a consecutive series of patients with gastrointestinal cancer. Serum free thiols were detected using a colorimetric detection method using Ellman's reagent. Short-term clinical outcomes were defined as 30-day complications (Clavien-Dindo ≥2) and l

SUBMITTER: Leimkuhler M 

PROVIDER: S-EPMC9174134 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature