Temporal changes in gastrointestinal fungi and the risk of autoimmunity during early childhood: the TEDDY study.

ABSTRACT: Fungal infections are a major health problem that often begin in the gastrointestinal tract. Gut microbe interactions in early childhood are critical for proper immune responses, yet there is little known about the development of the fungal population from infancy into childhood. Here, as part of the TEDDY (The Environmental Determinants of Diabetes in the Young) study, we examine stool samples of 888 children from 3 to 48 months and find considerable differences between fungi and bacteria. The metagenomic relative abundance of fungi was extremely low but increased while weaning from milk and formula. Overall fungal diversity remained constant over time, in contrast with the increase in bacterial diversity. Fungal profiles had high temporal variation, but there was less variation from mont

SUBMITTER: Auchtung TA 

PROVIDER: S-EPMC9174155 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature