Inflammatory potential of diet and colorectal carcinogenesis: a prospective longitudinal cohort.

ABSTRACT:

Background

Acknowledging the role of inflammation in colorectal carcinogenesis, this study aimed to evaluate the associations between diet-associated inflammation, as measured by the energy-adjusted dietary inflammatory index (E-DII^TM), and distinct stages of colorectal carcinogenesis.

Methods

The Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial enrolled participants without a colorectal cancer history, who were asked to complete baseline questionnaires and food frequency questionnaires. To estimate the associations between the E-DII and risks of newly incident colorectal adenoma, recurrent adenoma, and colorectal cancer, multivariable-adjusted Cox proportional hazards regression models were employed.

Results

Among 101,680 participants, with an

SUBMITTER: Li Z 

PROVIDER: S-EPMC9174157 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature