Patient-level proteomic network prediction by explainable artificial intelligence.

ABSTRACT: Understanding the pathological properties of dysregulated protein networks in individual patients' tumors is the basis for precision therapy. Functional experiments are commonly used, but cover only parts of the oncogenic signaling networks, whereas methods that reconstruct networks from omics data usually only predict average network features across tumors. Here, we show that the explainable AI method layer-wise relevance propagation (LRP) can infer protein interaction networks for individual patients from proteomic profiling data. LRP reconstructs average and individual interaction networks with an AUC of 0.99 and 0.93, respectively, and outperforms state-of-the-art network prediction methods for individual tumors. Using data from The Cancer Proteome Atlas, we identify known and potentia

SUBMITTER: Keyl P 

PROVIDER: S-EPMC9174200 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature