Spatial expression of IKK-alpha is associated with a differential mutational landscape and survival in primary colorectal cancer.

ABSTRACT:

Background

To understand the relationship between key non-canonical NF-κB kinase IKK-alpha(α), tumour mutational profile and survival in primary colorectal cancer.

Methods

Immunohistochemical expression of IKKα was assessed in a cohort of 1030 patients who had undergone surgery for colorectal cancer using immunohistochemistry. Mutational tumour profile was examined using a customised gene panel. Immunofluorescence was used to identify the cellular location of punctate IKKα expression.

Results

Two patterns of IKKα expression were observed; firstly, in the tumour cell cytoplasm and secondly as discrete 'punctate' areas in a juxtanuclear position. Although cytoplasmic expression of IKKα was not associated with survival, high 'punctate' IKKα expression was associated with

SUBMITTER: Patel M 

PROVIDER: S-EPMC9174220 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature