Developing an accurate empirical correlation for predicting anti-cancer drugs' dissolution in supercritical carbon dioxide.

ABSTRACT: This study introduces a universal correlation based on the modified version of the Arrhenius equation to estimate the solubility of anti-cancer drugs in supercritical carbon dioxide (CO₂). A combination of an Arrhenius-shape term and a departure function was proposed to estimate the solubility of anti-cancer drugs in supercritical CO₂. This modified Arrhenius correlation predicts the solubility of anti-cancer drugs in supercritical CO₂ from pressure, temperature, and carbon dioxide density. The pre-exponential of the Arrhenius linearly relates to the temperature and carbon dioxide density, and its exponential term is an inverse function of pressure. Moreover, the departure function linearly correlates with the natural logarithm of the ratio of carbon dioxid

SUBMITTER: Faress F 

PROVIDER: S-EPMC9174250 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature