Farnesoid X receptor functions in cervical cancer via the p14^ARF-mouse double minute 2-p53 pathway.

ABSTRACT:

Background

Cervical cancer is the second most common cancer among women living in developing countries. Farnesoid X receptor (FXR) is a member of the nuclear receptor family, which regulates the development and proliferation of cancer. However, the role of and molecular mechanism by which FXR acts in cervical cancer are still unknown.

Methods and results

The relationship between FXR and the proliferation of cervical cancer cell lines was detected by MTT and colony formation assays. Immunohistochemistry was used to detect the expression of FXR in cervical cancer tissue slides. Western blotting was used to detect the expression of p14^ARF, mouse double minute 2 (MDM2) and p53 when FXR was overexpressed or siRNA was applied. Western blotting was used to detect the exp

SUBMITTER: Huang X 

PROVIDER: S-EPMC9174312 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature