Inhibition of nuclear factor κB in the lungs protect bleomycin-induced lung fibrosis in mice.

ABSTRACT:

Background

Pulmonary fibrosis is a debilitating condition with limited therapeutic avenues. The pathogenicity of pulmonary fibrosis constitutes involvement of cellular proliferation, activation, and transformational changes of fibroblast to myofibroblasts. It is a progressive lung disease and is primarily characterized by aberrant accumulation of extracellular matrix proteins in the lungs with poor prognosis. The inflammatory response in the pathogenesis of lung fibrosis is suggested because of release of several cytokines; however, the underlying mechanism remains undefined. A genetic model is the appropriate way to delineate the underlying mechanism of pulmonary fibrosis.

Methods and results

In this report, we have used cc-10 promoter based IκBα mutant mice (IKBM, an inhib

SUBMITTER: Thakur D 

PROVIDER: S-EPMC9174314 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature