Vaccine effectiveness against COVID-19 related hospital admission in the Netherlands: A test-negative case-control study.

ABSTRACT:

Introduction

Real-world vaccine effectiveness (VE) estimates are essential to identify potential groups at higher risk of break-through infections and to guide policy. We assessed the VE of COVID-19 vaccination against COVID-19 hospitalization, while adjusting and stratifying for patient characteristics.

Methods

We performed a test-negative case-control study in six Dutch hospitals. The study population consisted of adults eligible for COVID-19 vaccination hospitalized between May 1 and June 28, 2021 with respiratory symptoms. Cases were defined as patients who tested positive for SARS-CoV-2 by PCR during the first 48 h of admission or within 14 days prior to hospital admission. Controls were patients tested negative at admission and did not have a positive test during the 2

SUBMITTER: Niessen FA 

PROVIDER: S-EPMC9174354 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature