Effect of A23187 ionophore treatment on human blastocyst development-a sibling oocyte study.

ABSTRACT:

Purpose

To investigate whether treatment with commercially available ready-to-use A23187 ionophore (GM508-CultActive) improves embryo development outcome in patients with a history of embryo developmental problems.

Methods

This is a uni-center prospective study in which sibling oocytes of patients with embryos of poor quality on day 5 in the previous cycle were treated or not with CultActive.

Results

Two hundred forty-seven metaphase II (MII) oocytes from 19 cycles performed between 2016 and 2019 were included in the study. After ICSI, the sibling oocytes were assigned to the treatment group or to the control group, following an electronically generated randomization list. A number of 122 MII were treated with CultActive and 125 MII had no treatment and were assigned

SUBMITTER: Mateizel I 

PROVIDER: S-EPMC9174380 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature