Zinc transporters ZIPT-2.4 and ZIPT-15 are required for normal C. elegans fecundity.

ABSTRACT:

Purpose

The requirement of zinc for the development and maturation of germ lines and reproductive systems is deeply conserved across evolution. The nematode Caenorhabditis elegans offers a tractable platform to study the complex system of distributing zinc to the germ line. We investigated several zinc importers to investigate how zinc transporters play a role in the reproductive system in nematodes, as well as establish a platform to study zinc transporter biology in germline and reproductive development.

Methods

Previous high throughput transcriptional datasets as well as phylogenetic analysis identified several putative zinc transporters that have a function in reproduction in worms. Phenotypic analysis of CRISPR-generated knockouts and tags included characterization of o

SUBMITTER: Sue AC 

PROVIDER: S-EPMC9174417 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature