Adenoma characteristics associated with post-polypectomy proximal colon cancer incidence: a retrospective cohort study.

ABSTRACT:

Background

Colorectal cancer (CRC) screening is less effective at reducing cancer incidence in the proximal colon compared to the distal colorectum. We aimed to identify adenoma characteristics associated with proximal colon cancer (PCC).

Methods

Endoscopy and pathology data for patients with ≥1 adenoma detected at baseline colonoscopy were obtained from 17 UK hospitals between 2001 and 2010. Multivariable Cox regression models were used to estimate adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for PCC, and, for comparison, distal CRC incidence, by adenoma characteristics.

Results

Among 18,431 patients, 152 and 105 developed PCC and distal CRC, respectively, over a median follow-up of 9.8 years. Baseline adenoma characteristics positively associated

SUBMITTER: Harewood R 

PROVIDER: S-EPMC9174477 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature