Traumatic brain injury-induced submissive behavior in rats: link to depression and anxiety.

ABSTRACT: Traumatic brain injury (TBI) affects millions of people worldwide, many of whom are affected with post-TBI mood disorders or behavioral changes, including aggression or social withdrawal. Diminished functionality can persist for decades after TBI and delay rehabilitation and resumption of employment. It has been established that there is a relationship between these mental disorders and brain injury. However, the etiology and causal relationships behind these conditions are poorly understood. Rodent models provide a helpful tool for researching mood disorders and social impairment due to their natural tendencies to form social hierarchies. Here, we present a rat model of mental complications after TBI using a suite of behavioral tests to examine the causal relationships between changes in

SUBMITTER: Boyko M 

PROVIDER: S-EPMC9174479 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature