Comprehensive screening for drugs that modify radiation-induced immune responses.

ABSTRACT:

Background

Combination therapy based on radiotherapy and immune checkpoint inhibitors (ICIs) was recently reported as effective for various cancers. The radiation-induced immune response (RIIR) is an essential feature in ICI-combined radiotherapy; however, the effects of drugs used concomitantly with RIIR remain unclear. We screened for drugs that can modify RIIR to understand the mutual relationship between radiotherapy and combined drugs in ICI-combined radiotherapy.

Methods

We established a high-throughput system with reporter gene assays for evaluating RIIR, focusing on factors acting downstream of the STING-IRF pathway, which can stimulate cancer cells, T cells, and dendritic cells. We further quantified the effects of 2595 drugs, including those approved by the Food an

SUBMITTER: Okumura M 

PROVIDER: S-EPMC9174493 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature