Dietary restriction and the transcription factor clock delay eye aging to extend lifespan in Drosophila Melanogaster.

ABSTRACT: Many vital processes in the eye are under circadian regulation, and circadian dysfunction has emerged as a potential driver of eye aging. Dietary restriction is one of the most robust lifespan-extending therapies and amplifies circadian rhythms with age. Herein, we demonstrate that dietary restriction extends lifespan in Drosophila melanogaster by promoting circadian homeostatic processes that protect the visual system from age- and light-associated damage. Altering the positive limb core molecular clock transcription factor, CLOCK, or CLOCK-output genes, accelerates visual senescence, induces a systemic immune response, and shortens lifespan. Flies subjected to dietary restriction are protected from the lifespan-shortening effects of photoreceptor activation. Inversely, photoreceptor inac

SUBMITTER: Hodge BA 

PROVIDER: S-EPMC9174495 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature