Impact of Human Genetic Variation on C-Reactive Protein Concentrations and Acute Appendicitis.

ABSTRACT:

Background

Acute appendicitis is one of the most common abdominal emergencies worldwide. Both environmental and genetic factors contribute to the disease. C-reactive protein (CRP) is an important biomarker in the diagnosis of acute appendicitis. CRP concentrations are significantly affected by genetic variation. However, whether such genetic variation is causally related to appendicitis risk remains unclear. In this study, the causal relationship between single-nucleotide polymorphisms (SNPs) associated with circulating CRP concentrations and the risk and severity of acute appendicitis was investigated.

Methods

CRP concentrations in serum of appendicitis patients (n = 325) were measured. Appendicitis was categorized as complicated/uncomplicated and gangrenous/non-gangrenous.

SUBMITTER: Ricano-Ponce I 

PROVIDER: S-EPMC9174512 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature