MSLN Correlates With Immune Infiltration and Chemoresistance as a Prognostic Biomarker in Ovarian Cancer.
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ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC9174524 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
MSLN Correlates With Immune Infiltration and Chemoresistance as a Prognostic Biomarker in Ovarian Cancer.
Li Yike Y Tian Wanjia W Zhang Hong H Zhang Zhijian Z Zhao Qinghe Q Chang Lei L Lei Ningjing N Zhang Weiwei W
Frontiers in oncology 20220525
Mesothelin (MSLN) is a glycoprotein with various expression degrees in different tumors including mesothelioma, ovarian cancer, pancreatic cancer, etc. MSLN is considered to play an important role in cell survival, proliferation, and tumor progression. Although the expression of MSLN in tumors makes it a potential therapeutic target, its mechanism of action is still unclear, especially its correlation with immune cells infiltration in the tumor microenvironment has not been investigated. In this ...[more]
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