Dataset Information

Herpesvirus and neurological manifestations in patients with severe coronavirus disease.

ABSTRACT:

Background

Certain clinical manifestations of coronavirus disease (COVID-19) mimic those associated with human herpesvirus (HHV) infection. In this study, we estimated the prevalence of herpesvirus in patients with COVID-19 and determined if coinfection is associated with poorer outcomes and neurological symptoms.

Methods

We analyzed samples of 53 patients diagnosed with COVID-19. The samples were evaluated for the presence of alphaherpesviruses, betaherpesviruses, and gammaherpesviruses, and the viral loads were quantified using quantitative polymerase chain reaction (qPCR) method.

Results

Among the patients, in 79.2% had detection at least one type of herpesvirus. HHV-6 (47.2%), cytomegalovirus (43.3%), and HHV-7 (39.6%) showed the highest detection rates. Patients with a high severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) load were more likely to show herpes simplex virus 1 detection (p = 0.037). Among patients coinfected with SARS-CoV-2 and HHVs, 26.4% showed central nervous system-associated neurological symptoms and herpetic manifestations. A statistically significant association was observed between neurological changes and HHV-6 detection (p = 0.034).

Conclusions

The findings showed a high prevalence of herpesvirus in patients with COVID-19. Furthermore, even though SARS-CoV-2 and HHV coinfection was not associated with poorer outcomes, the findings demonstrated the association between neurological symptoms and HHV-6 detection.

SUBMITTER: Carneiro VCS

PROVIDER: S-EPMC9174631 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature

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Publications

Herpesvirus and neurological manifestations in patients with severe coronavirus disease.

Carneiro Vanessa Cristine de Souza VCS Alves-Leon Soniza Vieira SV Sarmento Dmitry José de Santana DJS Coelho Wagner Luis da Costa Nunes Pimentel WLDCNP Moreira Otacilio da Cruz ODC Salvio Andreza Lemos AL Ramos Carlos Henrique Ferreira CHF Ramos Filho Carlos Henrique Ferreira CHF Marques Carla Augusta Barreto CAB da Costa Gonçalves João Paulo JP Leon Luciane Almeida Amado LAA de Paula Vanessa Salete VS

Virology journal 20220608 1

<h4>Background</h4>Certain clinical manifestations of coronavirus disease (COVID-19) mimic those associated with human herpesvirus (HHV) infection. In this study, we estimated the prevalence of herpesvirus in patients with COVID-19 and determined if coinfection is associated with poorer outcomes and neurological symptoms.<h4>Methods</h4>We analyzed samples of 53 patients diagnosed with COVID-19. The samples were evaluated for the presence of alphaherpesviruses, betaherpesviruses, and gammaherpes ...[more]

PMID: 35676707

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Dataset Information

Herpesvirus and neurological manifestations in patients with severe coronavirus disease.

Background

Methods

Results

Conclusions

Publications

Herpesvirus and neurological manifestations in patients with severe coronavirus disease.

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