Trained Immunity in Perivascular Adipose Tissue of Abdominal Aortic Aneurysm-A Novel Concept for a Still Elusive Disease.

ABSTRACT: Abdominal aortic aneurysm (AAA) is a chronic, life-threatening vascular disease whose only therapeutic option is a surgical repair to prevent vessel rupture. The lack of medical therapy results from an inadequate understanding of the etiopathogenesis of AAA. Many studies in animal and human models indicate a 'short-circuiting' of the regulation of the inflammatory-immune response as a major player in the AAA chronic process. In this regard, perivascular adipose tissue (PVAT) has received increasing interest because its dysfunction affects large arteries primarily through immune cell infiltration. Consistently, we have recently produced evidence that innate and adaptive immune cells present in the PVAT of AAAs contribute to sustaining a damaging inflammatory loop. However, it is still uncle

SUBMITTER: Piacentini L 

PROVIDER: S-EPMC9174671 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature